Can acid indigestion cause back discomfort? Only victims of esophageal reflux (achalasia) can experience indigestion muscle and back discomfort. Victims of jaundice (bile), an ailment for the liver and gallbladder, commonly experience sickness, vomiting, and bloating. In severe instances, a fatty accumulation (biliary sludge) in the bile ducts can block the flow of bile out from the gallbladder...